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Inoperable tumors are those that are located in an inaccessible place in the brain that brain surgeons cannot reach. Alternatively, although they may be able to reach the tumor, to remove it, the surgeons may have to destroy or damage so much nearby brain tissue so that the surgery may damage the patient as much as the tumor. Inoperable tumors can be of any type or size. What makes a tumor inoperable is whether or not a surgeon is confident that they can access the tumor without disrupting other significant brain tissues such as those necessary for essential body functions (for example, speech or movement). Other tumors are deemed inoperable when they are so penetrated by blood vessels that removal of the tumor and its vascular system is likely to severely damage or cause death in the patient. The surgeon determines if a patient's brain tumor is inoperable, so it is advisable to seek a second opinion from another surgeon as another brain surgeon may consider the tumor to be "operable."

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