If you start to notice side effects, such as the beginning stages of gynecomastia, excessive water retention, or high blood pressure despite using anti-estrogen medications to prevent them, then your Deca Durabolin dosage is likely too high for your body. Just as you titrated your dose upward, begin to titrate back down if you notice these bothersome side effects. As an example, if you were taking four 100mg doses per week, use four 75mg doses per week, instead. This will shave 100mg per week off of your overall dose, and you should notice a difference. If not, go down to three 75mg doses per week.
Re: HPA axis. As above, EDS affects way more than ligaments; it is a collagen disorder, not a ligament disorder. Collagen is present throughout the body. I have had my stress hormones tested, because my BP was so haywire that pheochromocytoma was suspected. The stress hormones were all normal, it was the response to them that was flaky. I know of at least two other people who went down the same road. Of course, that is anecdote, not data , but there are studies of our autonomic response to being upright. Suffice it to say, that the response is far from typical, and is characterized by extreme fluctuations between sympathetic and parasympathetic systems, instead of the smooth response in normal people.