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One strange side-effect of the healing and re-wiring of the facial nerve is how my tear ducts in my right eye and right side of my nose react when I eat. Because these nerves are so close the ones that control the salivary glands, it appears they now react by watering and running when I eat. It’s now easy for people to see when I think food is good because it looks like my right eye is tearing up and I have to blow my nose! I admit, it’s kind of strange, but it really isn’t a big deal, and a small inconvenience considering where I was.

This goes into more detail about the genetic mutation responsible for Gilbert's Syndrome. Genetic mutations are given a asterisk notation, and the mutation causing Gilbert's Syndrome is called UGT1A1*28. The mutation is not in the structure of the enzyme, which is fine, but in the amount of it that is produced. The area responsible for this is called the promoter region. In Caucasian and African populations, this is the most common cause of Gilbert's Syndrome, while in Japanese populations, a mutation known as G71R alters the effectiveness of the UGT1A1 enzyme with nearly identical results.

The genotype variation specifically refers to the Rs4680 SNP , which is one of the SNPs that services like 23andMe test for. So someone could sign up for 23andMe testing and only start buying modafinil if the results are favorable; considering that 23andMe sometimes holds sales at $100 or $200 and that one could easily spend this much on a single order of modafinil, testing first may not be a bad idea. But on the other hand: anecdotes are hard to come by of people who have used modafinil, been genotyped, and checked that SNP, yet I have been told by 2 Val/Val users that sublingual Modalert/Waklert did nothing for them (personal communication; 2 ) and by 4 Met/Met users that modafinil worked for them and there are 2 further anecdotes on Hacker News & Reddit ( 1 , 2 , multiple ). Besides the dubiousness of such a large effect size from a single SNP, candidate-gene results frequently disappear ( Ioannidis et al 2011 ), like what happened when 12 highly cited IQ-related SNPs failed to replicate in a well-powered 2011 GWAS and subsequent GWASes (replication being the coin of science ). As of 23 May 2013, there do not seem to have been any followup citing studies of this SNP association. Given the weakness of the evidence, one would probably have to be on the razor’s edge of deciding to try or not try modafinil before your result would make the difference.

The amount of oxycodone that is safe for you depends on your body’s current exposure to opioids . The amount of oxycodone that is too much for you is relative to how tolerant your body already is to oxycodone, opiates or opioids. Safe dosing levels of oxycodone will also depend upon the type of oxycodone you are taking. Oxycodone in immediate action or controlled release form is available in different doses, and has different actions. Furthermore, as doctors increase doses, they consider a number of different variables, including your age, weight, general health and other medication.. So, how much oxycodone is too much really depends on your specific case.

The amount of tramadol you need to take to overdose depends on your previous exposure to opioids. You can take more tramadol safely if your body is already tolerant to tramadol, opiates, or opioids. The safe doses for tramadol will vary between different strengths and formulas of tramadol. For example, if tramadol is mixed with other medications, such as acetaminophen, it can be much easier to overdose on the combined product. And if you’ve developed a tolerance to tramadol, you’ll have to have your dosage increased under a doctor’s direction – and you should never start taking more without your doctor’s input to avoid the risk of accidental overdose.

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The amount of oxycodone that is safe for you depends on your body’s current exposure to opioids . The amount of oxycodone that is too much for you is relative to how tolerant your body already is to oxycodone, opiates or opioids. Safe dosing levels of oxycodone will also depend upon the type of oxycodone you are taking. Oxycodone in immediate action or controlled release form is available in different doses, and has different actions. Furthermore, as doctors increase doses, they consider a number of different variables, including your age, weight, general health and other medication.. So, how much oxycodone is too much really depends on your specific case.

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