This drug was first produced in 1964 by a company called Searle. It was designed to be a safe and mind anabolic steroid and in low doses was well tolerated by women and children. Oxandrolone is a Class I anabolic, mildly androgenic steroid, which makes it safe to use in many cases. This drug has been used for anything from, burn victims to treatment of osteoporosis as it provides calcium to the body which will aid in bone regeneration. However in 1989 this drug was discontinued by Searle Laboratories partly due to the illegal use among bodybuilders. Around 6 years later Bio-Technology General Corp negotiated a deal with Searle where they would continue to manufacture the drug Anavar and supply it to BTG. This is when a press release went out stating its effects on involuntary weight loss and focused itself on HIV/AID’s wasting indications which were approved by the FDA where they were able to dictate the price by it being granted Orphan Drug status by the Food and Drug Administration.
As with all anabolic steroids Oxandrolone will suppress natural testosterone production in men. Testosterone suppression does vary from steroid to steroid in terms of the rate and Oxandrolone is one of the milder forms. However, most all men will still need some form of exogenous testosterone if they are using Oxandrolone at any significant dose for any significant time. Those who do not supplement with testosterone have an excellent chance of putting themselves into a low testosterone condition. For the purpose of information a performance level dosing of Oxandrolone will suppress natural testosterone production in most men by dropping serum testosterone levels by 50%. This will put most men into a low level state and if not certainly in a below optimal state.
Once the use of Oxandrolone is done and it along with all anabolic steroids has cleared the body natural testosterone production will begin again. It’s important to note that recovering prior natural levels assumes no prior low level condition existed and that there was no damage done to the HPTA during steroid use . Most men will need a Post Cycle Therapy (PCT) plan to aid in recovery, but they should also note that PCT will not promote full recovery. It takes several months to recover from anabolic steroid use and there’s no guarantee that you always will even with the best PCT plan in the world.
Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes.