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The AR is important for therapeutic target in prostate cancer , thus many different inhibitors have been developed, primarily targeting the ligand binding domain of the protein, while inhibitors that target the N-terminal domain of the protein are still under development. [52] AR ligands can either be classified based on their structure ( steroidal or nonsteroidal ) or based on their ability to activate or inhibit transcription ( agonists or antagonists ). [53] Sulforaphane , a phytochemical derived from broccoli or the HSP90 inhibitor ganetespib or the NRF2 activator bardoxolone methyl has been shown to degrade both AR and AR-V7 and thus enhance the efficacy of antagonists like enzalutamide [54] [55] .

A number of nandrolone cases in athletics occurred in 1999, which included high-profile athletes such as Merlene Ottey , Dieter Baumann and Linford Christie . [42] However, the following year the detection method for nandrolone at the time was proved to be faulty. Mark Richardson , a British Olympic relay runner who tested positive for the substance, gave a significant amount of urine samples in a controlled environment and delivered a positive test for the drug, demonstrating that false positives could occur, which led to an overhaul of his competitive ban. [43]

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