Oxymetholone (also known as anapolon or anadrol) is a very drastic synthetic steroid, 17-alpha-alkylated modification of dihydrotestosterone. It was developed for the treatment of osteoporosis and anaemia, as well as to stimulate muscle gain in malnourished and debilitated patients. Oxymetholone has been approved by the American Food and Drug Administration (FDA) for use in humans. Later there where created non-steroidal drugs that effectively could treat anaemia and osteoporosis; because of this anapolon lost his popularity and by 1993 Syntex decided to cease the production of the drug, as well as other manufacturers did.
Spironolactone is typically used at a low dosage of 25 to 50 mg/day in the treatment of heart failure,     while it is used at low to high dosages of 25 to 200 mg/day in the treatment of essential hypertension ,   and at high dosages of 100 to 400 mg/day for hyperaldosteronism and ascites due to cirrhosis .     The medication is typically used at high dosages of 100 to 200 mg/day in the treatment of skin and hair conditions in women,      and at high dosages of 100 to 400 mg/day in feminizing hormone therapy for transgender women.