The common side-effects of oxymetholone include depression, lethargy, headache, swelling, rapid weight gain, priapism , changes in skin color, urination problems, nausea , vomiting , stomach pain (if taken on an empty stomach), loss of appetite, jaundice , breast swelling in men, feeling restless or excited, insomnia , and diarrhea .  In women, side effects also include acne , changes in menstrual periods , deepened voice, hair growth on the chin or chest, male pattern baldness , enlarged clitoris , and changes in sex drive .  Because of its 17α-alkylated structure, oxymetholone is highly hepatotoxic . Long term use of the drug can cause a variety of serious ailments, including hepatitis , liver cancer , and cirrhosis ; therefore periodic liver function tests are recommended for those taking oxymetholone.  It is dangerous to take oxymetholone in high dosages (100mg+) for periods of time exceeding four weeks.