James E Moon, MD, FACP, FIDSA Director, Malaria Vaccine Branch, Military Malaria Research Program, Walter Reed Army Institute of Research; Assistant Professor, Department of Medicine, Uniformed Services University of the Health Sciences
James E Moon, MD, FACP, FIDSA is a member of the following medical societies: American College of Physicians-American Society of Internal Medicine , American Society of Tropical Medicine and Hygiene , Armed Forces Infectious Diseases Society , Infectious Diseases Society of America
Disclosure: Nothing to disclose.
Data are limited regarding IgM antibody tests and timing of the IgM response in unvaccinated persons; even less information exists on serologic methods for laboratory confirmation for vaccinated persons. A negative IgM result should not be used to rule out the diagnosis. A positive IgM in the absence of rash should not be used to confirm a diagnosis. Furthermore, a 4-fold rise in IgG antibody may not occur in vaccinated persons. VZV IgG avidity testing is a method that can be used to distinguish between primary VZV infection and past infection but this method is not widely available. Therefore, DNA detection methods are the laboratory methods of choice for diagnosis.